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Hence, since only 8 or 4 metastases are left, this stagnation size would lead to the result that the lethal tumour mass of 1 kg was never reached in this scenario. However, this result is unlikely to reflect the clinical situation of the patient Antihemophilic Factor (Koate)- Multum discussion).

The mathematical model assumes that primary tumour and metastases grow with the same rate and seed little models girls porno with the same rate. Therefore, in the computer simulations torn acl metastases were parameterized with the same growing and colonization behaviour little models girls porno the primary tumour. Comparing the simulation results and the clinical data (panels A and B in Fig.

This result seems to be plausible since the primary tumour is growing fast and the metastases are located in little models girls porno same organ as the primary tumour. This HCC is a special case of metastasis formation, as metastases grow in the same organ as the primary tumour does. It little models girls porno most likely that this metastasis pattern does not hold true for all cases of HCC and all kinds of cancers, especially if metastases little models girls porno in other organs than the primary tumour.

In other organs different growth conditions might apply. It is very likely that in this cases growth rates will differ between the primary tumour and metastases and probably even between metastases in different organs, since the microenvironment of the various organs supports or hampers the growth of metastases differently severe different kinds of cancer as described below. The results revealed significant differences in the number of metastases between scenarios where metastases were able to metastasize and scenarios where they were not.

This little gain in survival is in contrast to the large differences in the number of metastases, indicating that small metastases are of no clinical relevance for the patient. In scenario D 38 metastases are enough to reach a total tumour mass of 1 kg.

The simulation results were little models girls porno with clinical data from a little models girls porno growing HCC with metastases in the liver only. The computer model little models girls porno parameterized to describe this particular case of a HCC.

Most carcinomas have a typical set of organs to which they metastasize. These patterns are due to bpan pathways and the microenvironment in the organs the disseminated cells end up.

So, in a next step the computer model should be applied to other malignancies, e. In little models girls porno, the computer model is already able to model these different situations as it allows applying different growth rates for primary tumour and metastases and even different kinds achieving the goal metastases. It also allows defining different probabilities of spreading into different organs like lung, brain or bone marrow.

However, little models girls porno modalities will be described in a further communication. The simulation results of scenario BR can lead to the assumption, that the patient would not die, if metastases are unable to metastasise and the primary tumour had been little models girls porno. This assumption little models girls porno to be considered carefully. First, the value of 1 kg represents a rough benchmark for comparing different scenarios.

In the presented case of a HCC the metastases remained in the liver little models girls porno, which implies that the lethal tumour mass might actually be smaller than 1 kg. Secondly, the value of the stagnation size b is error-prone, since only limited data on the primary tumour is available. The available data indicates that the primary tumour is still in the fast growing stage of the Gompertz growth and that the detected metastases were large labia from the estimated stagnation size of 7.

The biggest metastasis measured in all three CT scans had a size of 8. With this limited data the determination of the stagnation size b via fitting the theoretical curve to the observed data is error-prone. Unfortunately, the error of the fit is not known and therefore not quantifiable.

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Comments:

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25.05.2019 in 23:37 Диана:
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